America Ammayi is about Samantha who has set out on a mission to re-unite her mother with her family who disowned her when she decided to get married to an American. Though Samantha is an American born, her family values are deeply rooted into the Indian System. The maternal side of Samantha has disowned her family as her mother got married to an American without their consent. As years pass by, Samantha's mother, Kalyani falls ill and wishes to re-unite with her family before she succumbs to her illness. Samantha takes this as a challenge and embarks upon a journey to India with an aim to bring them together. The story unfolds on how Samantha enters her grand parents' house while she tries to convince them to accept Kalyani back into the family. During her stay, she falls in love with Surya who is her maternal uncle's son. Will Samantha manage to unite her mother with her maternal family?