'Naagini' is an intriguing story of revenge revolving around Naagini, an inhabitant of Naglok, or world of snakes. Naagini is shocked when her parents are killed by a ruthless human being to get hold of 'Naagmani'. To bring her parents back to life, Naagini must bring back the Naagmani. In order to avenge her parents' death, and to bring the Naagmani back to Naaglok, Naagini takes form of a beautiful girl, and ventures out in search of the culprit. Things do not remain the same for Naagini, now known as Amrutha, when she falls in love with the son of her parents' murderer. Will Amrutha take revenge and bring back the Naagmani to revive her parents' life, or will she sacrifice the Naagmani for sake of her love?